Lopress

Generic Name:: Losartan potassium
Active Ingredient:: Losartan potassium 50mg
Group:: Cardiovascular System
Subgroup:: Renin-Angiotensin System Agents
ATC code:: C09C A01


Application:: Oral administration
Dosage Form and Strength:: Pack of 28 tablets in plastic HDPE containers

Description:

Lopress is an angiotensin II receptor blocking agent (type AT1) for oral administration. Lopress is used to treat hypertension (high blood pressure) and heart failure. Angiotensin II connects to the AT1 receptor that is present in many tissues (i.e. smooth muscle of blood vessels, adrenal glands, kidneys and heart) and elicits various important biological effects, including the contraction of blood vessels and the release of aldosterone. Angiotensin II also stimulates the proliferation of smooth muscle cells. On the basis of chemical binding measurements and pharmacological measurements, it is revealed that it connects specifically to the AT1 receptor. Both losartan and its pharmacologically active carboxylic acid metabolite (E-3174) block all biologically important effects of angiotensin II. This has been demonstrated in vitro and in vivo, independent of its metabolic pathway. Lopress connects specifically to the AT1 receptor and does not connect to nor block any other hormone receptors or ionic passages which are important for function of the cardiovascular system. Furthermore, Lopress does not block ACE (kinase II), the enzyme that metabolizes bradykinin.

SPC document

Lopress SPC